Drug-induced liver diseasešŸŽ„

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Drug-induced liver disease

Introduction

Hepatocellular

  • Alcohol
  • Amiodarone
  • Isoniazid
  • Rifampicin
  • MAO inhibitors
  • Methyldopa
  • Sodium valproate
  • Statins

Cholestatic

  • Co-amoxiclav
  • Erythromycin
  • Flucloxacillin
  • Oral contraceptive pill
  • Chlorpromazine
  • Sulfonylureas
  • Testosterone

Liver cirrhosis

  • Amiodarone
  • Methotrexate

FAQ from our users

How does alcohol affect the liver?
  • Alcoholic liver disease (ALD) encompasses a varied clinical and histological spectrum. On one end of the spectrum is fatty liver (steatosis), which is reversible with abstinence, and the more severe alcoholic hepatitis and fibrosis, which may or may not improve with abstinence. On the other end of the spectrum are cirrhosis and end-stage liver disease, conditions that typically are irreversible and have a poor prognosis. In addition, continued consumption of alcohol combined with obesity can further increase a person’s risk of cancer (hepatocellular carcinoma).

Common pitfalls in a clinical setting

Common pitfalls in a clinical setting
  • Always remember that drug interactions and the risk of hepatotoxicity increase the likelihood of drug-induced liver disease.